ASSESSMENT OF MICROBIAL INFECTION SUSPECTIBILITY IN RELATION TO ADENOSINE DEAMINASE AND GYCOSYLATED HEMOGLOBIN LEVEL IN TYPE 2 DIABETIC INDIVIDUALS; A CASE CONTROL STUDY IN NORTH WESTERN PART OF UTTAR PRADESH

Abstract

Background: Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia resulting from defects in insulin secretion, action, or both. Chronic hyperglycemia can lead to secondary damage in various organ systems, particularly the kidneys, eyes, nerves, and blood vessels.  Materials & methods: The present study included 150 subjects, 75 of whom were cases of type 2 DM from the Outpatient Department of Varun arjun Medical College and  Rohilkhand Hospital, and 75 healthy individuals as controls. Results: A total of 150 patients were recruited for the study, which included 43 patients with Type II Diabetes Mellitus and glycated hemoglobin levels greater than 8%, 32 patients with Type II Diabetes Mellitus and glycated hemoglobin levels of 8% or lower, and 75 healthy individuals who served as controls. The following parameters were analyzed: fasting plasma glucose, glycated hemoglobin (HbA1c), and serum adenosine deaminase (ADA). The results showed that blood sugar levels, mean HbA1c, and serum ADA levels were significantly higher in the diabetic group compared to the control group (p = 0.0001). The data was analyzed using SPSS software Conclusion: Increased ADA (Adenosine Deaminase) levels can indicate glycemic status and insulin resistance in patients with type 2 diabetes. Analyzing these levels helps assess glycemic control and can serve as an early warning for diabetic complications, allowing for preventive measures that improve health out
comes.