CLINICO-BIOCHEMICAL PROFILE OF THYROID AND PROLACTIN HORMONE LEVELS AMONG INFERTILE WOMEN IN TERTIARY CARE HOSPITAL

Abstract

Background: Thyroid dysfunction is prevalent in the female population and is known to affect reproductive function and even pregnancy. Hyperprolactinemia is also one of the common problems which are encountered in reproductive disorder. Objective of the study was to determine the prevalence of thyroid profile abnormalities with or without elevated levels prolactin hormone in infertile women. Materials and Methods: The present descriptive study was conducted after taking Ethical committee approval. A written consent form was obtained after explaining the procedure and the study protocol to each subject. The cases consisted 100 female subjects who were suffering from primary infertility and had been referred the Department of Biochemistry. The inclusion criteria for the selection of cases were diagnosis of primary infertility, aged between 20-40 years. Results: Mean T3, T4 and TSH levels were 1.31, 8.32 and 3.05 respectively with mean prolactin levels being 22.74. 13% of the infertile women had hypothyroidism and 3% had hyperthyroidism. There were a statistically significant high prolactin levels and TSH levels in hyperprolactinemic infertile women compared to normoprolactinaemic infertile women. Conclusion: Hyperprolactinemia with thyroid disorders could play a significant factor in infertility and therefore during the workup of infertile women, T3, T4, TSH and prolactin levels should be estimated.