STUDY OF HIGH DENSITY LIPOPROTEIN LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS AND IT'S ASSOCIATION WITH DIABETIC NEPHROPATHY AND RETINOPATHY

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a major metabolic disorder associated with significant microvascular complications, particularly diabetic retinopathy and nephropathy. Dyslipidemia is commonly observed in diabetic patients and is increasingly recognized as an important contributor to the development and progression of these complications Objective: To assess the High Density Lipoprotein levels in patients with type 2 diabetes mellitus and to evaluate its association with diabetic retinopathy and nephropathy Methods: A cross-sectional study was conducted among patients with T2DM attending the outpatient and inpatient departments of General Medicine at K.R. Hospital, Mysore Medical College and Research Institute. Data on high-density lipoprotein (HDL) other relevant markers, were collected and analyzed. The presence of diabetic retinopathy and nephropathy was assessed, and their association with lipid abnormalities was evaluated using appropriate statistical methods. Result: Reduced or dysfunctional HDL was e significantly associated with both diabetic retinopathy and nephropathy. These findings are consistent with existing literature and support the role of lipid abnormalities as independent risk factors. Conclusion: reduced or dysfunctional HDL plays a significant and multifaceted role in the development and progression of microvascular complications in type 2 diabetes mellitus. The findings indicate that abnormalities with reduced or dysfunctional HDL, are closely associated with both diabetic retinopathy and nephropathy.